Oura Ring Gen 4 sensor data, not clinical measurementsN=1 case study, not validated for clinical decisionsHEV diagnosed Mar 18; Day 166 post-ruxolitinibMore
Consumer wearable data can support exploratory review only. The HEV diagnosis, temporally confounded with treatment start, remains a material confounder.

Tau-U Effect Size Analysis

Single-Case Experimental Design (SCED) Phase Comparisons
SUMMARY

Effect Size Summary (A vs B+C)

TAU-U: Mean RMSSD
Large
0.638
Large effect | p<0.001 (trend-corrected)
A vs B+C | NAP=93.1%
TAU-U: Lowest Heart Rate
Large
0.632
Large effect | p<0.001 (trend-corrected)
A vs B+C | NAP=92.0%
TAU-U: Average Heart Rate
Large
0.604
Large effect | p<0.001 (trend-corrected)
A vs B+C | NAP=91.0%
TAU-U: Sleep Efficiency
Moderate
0.467
Moderate effect | p<0.001 (trend-corrected)
A vs B+C | NAP=79.7%
RESULTS

Tau-U Results: All Comparisons

Comparison Metric nA nB MeanA MeanB Dir Tau-U 95% CI p-value Effect NAP Note
A vs B (Jakavi Effect)Mean RMSSD672210.010.9-0.192 *[-0.471, +0.088]p<0.001weak62.7%⚠ corrected
A vs B (Jakavi Effect)Lowest Heart Rate641976.772.9-0.114 *[-0.411, +0.184]p=0.046weak69.7%⚠ corrected
A vs B (Jakavi Effect)Average Heart Rate641985.281.4-0.162 *[-0.459, +0.136]p=0.005weak69.1%⚠ corrected
A vs B (Jakavi Effect)Sleep Efficiency641978.679.9-0.018[-0.316, +0.279]p=0.749weak62.4%⚠ corrected
B vs C (BB Marginal Effect)Mean RMSSD2214410.928.6+0.943 *[+0.683, +1.000]p<0.001very large97.1%
B vs C (BB Marginal Effect)Lowest Heart Rate1914172.960.1+0.856 *[+0.579, +1.000]p<0.001very large92.8%
B vs C (BB Marginal Effect)Average Heart Rate1914181.469.1+0.835 *[+0.557, +1.000]p<0.001very large91.7%
B vs C (BB Marginal Effect)Sleep Efficiency1914179.983.0+0.500 *[+0.223, +0.778]p<0.001moderate75.0%
A vs B+C (Combined Post)Mean RMSSD6716610.026.2+0.638 *[+0.474, +0.802]p<0.001large93.1%⚠ corrected
A vs B+C (Combined Post)Lowest Heart Rate6416076.761.6+0.632 *[+0.464, +0.800]p<0.001large92.0%⚠ corrected
A vs B+C (Combined Post)Average Heart Rate6416085.270.6+0.604 *[+0.436, +0.772]p<0.001large91.0%⚠ corrected
A vs B+C (Combined Post)Sleep Efficiency6416078.682.7+0.467 *[+0.299, +0.635]p<0.001moderate79.7%⚠ corrected
DESCRIPTIVE

Phase Descriptive Statistics

Phase Metric n Mean SD Min Max
AMean RMSSD6710.02.45.018.4
ALowest Heart Rate6476.75.764.096.0
AAverage Heart Rate6485.26.869.8113.9
ASleep Efficiency6478.63.471.091.0
BMean RMSSD2210.92.26.917.7
BLowest Heart Rate1972.94.067.084.0
BAverage Heart Rate1981.44.276.496.4
BSleep Efficiency1979.94.069.087.0
CMean RMSSD14428.68.58.055.4
CLowest Heart Rate14160.17.435.086.0
CAverage Heart Rate14169.17.458.197.8
CSleep Efficiency14183.06.158.092.0
METHODOLOGY

Methodology & Interpretation

Methodology

Tau-U (Parker, Vannest, Davis & Sauber, 2011) is the recommended effect size for single-case experimental designs (SCED). It quantifies the degree of nonoverlap between phases while optionally correcting for baseline trend.

Interpretation Scale

|Tau| < 0.20 = Weak
0.20 – 0.60 = Moderate
0.60 – 0.80 = Large
> 0.80 = Very large

Key Details

  • Positive Tau = improvement (direction-adjusted per metric)
  • Baseline correction: If Phase A shows a significant trend (Kendall tau, p<0.05), Tau-U is corrected by subtracting the baseline S statistic. A ⚠ symbol marks corrected values.
  • NAP (Nonoverlap of All Pairs) is a complementary measure: probability that a random Phase B observation exceeds a random Phase A observation (after direction adjustment). NAP > 0.93 = large, 0.66–0.92 = medium, < 0.66 = weak (Parker & Vannest, 2009).
  • * = statistically significant at p < 0.05

Phases

  • Phase A (Pre-treatment): Jan 08 – Mar 15, 2026
  • Phase B (Jakavi only): Mar 16 – Apr 07, 2026
  • Phase C (Jakavi + Beta-blocker): Apr 08, 2026 – present