Oura Ring Gen 4 sensor data, not clinical measurementsN=1 case study, not validated for clinical decisionsHEV diagnosed Mar 18; Day 0 post-ruxolitinibMore
Consumer wearable data can support exploratory review only. The HEV diagnosis, temporally confounded with treatment start, remains a material confounder.

Patient 2 Changepoint Investigation

TOTAL CHANGEPOINTS
Info
14
VALIDATED
In range
2
Near known events
ARTIFACT
6
Near gap boundaries
GENUINE
Info
3
Clear metric shifts
INVESTIGATE
Watch
3
Questions for Patient 2
SUMMARY

Executive Summary

Analysis of 14 changepoints discovered by the 4-method consensus algorithm across 5 years of Oura Ring data. P2's data spans from early 2021 with significant gaps totaling approximately 1301 days of missing data across 9 gap periods.

The highest-consensus changepoint (C=9 on 2022-01-23) falls during P2's Australia stay (Dec 2021 - May 2022), suggesting genuine physiological adaptation to the timezone shift and environment change.

Of the 14 changepoints: 2 validated against known events, 6 classified as data artifacts (within 3 days of gap boundary), 3 genuine metric shifts, and 3 requiring follow-up with Patient 2.

TIMELINE

5-Year Biometric Timeline with Changepoints

Vertical lines mark changepoints (colored by validation status). Gray bands indicate data gap periods. Red lines mark known life events. Labels show consensus score (C=N).

TOP CHANGEPOINTS

Top 6 Changepoints: Before vs. After

Comparison of key metrics in the 14-day window before and after each high-consensus changepoint. Grouped by HRV, Heart Rate, and Sleep Efficiency.

AUSTRALIA

Australia Trip Deep Dive (Dec 2021 - Feb 2022)

Patient 2 arrived in Australia on Dec 18, 2021. Data is available for 60 days (2021-12-18 to 2022-02-18). The red shaded zone marks the first 7 days (jet lag recovery window). The amber line marks the C=9 changepoint on Jan 23, 2022.

HRV: Pre 47.6 -> Aus 52.8 (+5.1 ms)
HR: Pre 62.5 -> Aus 62.5 (+0.0 bpm)
GAP PROXIMITY

Gap Proximity Analysis

Distance (in days) from each changepoint to the nearest data gap boundary. Changepoints within 3 days of a gap are classified as potential artifacts. Color indicates validation status.

VALIDATION

Changepoint Validation Summary

All 14 changepoints ranked by consensus score with classification, dominant metric shift, and data availability.

Date Consensus Validation Type Gap Dist. Top Metric Shift Data (B/A)
2022-01-23 9 VALIDATED Travel/timezone 27d Active Calories +27% 14d / 15d
2021-05-31 8 GENUINE Recovery milestone 264d Daily Steps -47% 14d / 15d
2021-10-29 8 GENUINE Lifestyle shift 113d Total Sleep +16% 14d / 15d
2022-05-06 8 VALIDATED Travel/timezone 2d Active Calories -97% 4d / 3d
2023-07-06 8 INVESTIGATE Lifestyle shift 63d Avg Heart Rate +3% 14d / 13d
2023-12-30 8 INVESTIGATE Lifestyle shift 17d Active Calories +15% 13d / 15d
2022-08-08 7 ARTIFACT Data artifact 0d Active Calories -38% 2d / 1d
2024-06-03 6 ARTIFACT Data artifact 1d Active Calories +125% 2d / 3d
2025-02-03 6 INVESTIGATE Recovery milestone 4d Daily Steps -46% 5d / 8d
2024-01-22 5 ARTIFACT Data artifact 3d Daily Steps -18% 11d / 7d
2025-02-11 5 ARTIFACT Data artifact 0d Active Calories -90% 12d / 1d
2025-03-25 5 ARTIFACT Data artifact 0d HRV (RMSSD) +37% 1d / 3d
2021-02-20 2 GENUINE Lifestyle shift 364d Active Calories +60180% 3d / 15d
2025-12-02 2 ARTIFACT Data artifact 1d Active Calories -42% 2d / 5d
TRAJECTORY

Long-Term Trajectory Segmentation

P2's biometric data split into wearing segments between gap periods. Shows baseline shifts across years.

Start End Days HRV (ms) HR (bpm) Efficiency
2021-02-17 2022-02-18 363 52.6 +/- 10.4 63.0 +/- 4.3 83%
2023-04-30 2023-09-06 128 47.6 +/- 7.4 60.9 +/- 3.7 83%
2023-12-14 2024-01-24 38 51.9 +/- 6.1 59.8 +/- 2.8 80%
2025-01-31 2025-02-10 10 48.6 +/- 6.7 58.2 +/- 3.2 79%
2026-03-26 2026-04-05 11 42.1 +/- 4.0 59.0 +/- 2.1 85%
QUESTIONS

Questions for Patient 2

The following changepoints could not be explained by data gaps or known events. Answers from Patient 2 would help validate the detection system.

  1. Around 2023-07-06: Your Avg Heart Rate increased by 3%. Did anything notable happen around this date? (illness, travel, lifestyle change, medication, stress event?)
  2. Around 2023-12-30: Your Active Calories increased by 15%. Did anything notable happen around this date? (illness, travel, lifestyle change, medication, stress event?)
  3. Around 2025-02-03: Your Daily Steps decreased by 46%. Did anything notable happen around this date? (illness, travel, lifestyle change, medication, stress event?)