Composite Biomarkers
Post-HSCT Monitoring - 33.1 months
ADSI
Elevated59.0/100
Autonomic Dysfunction | stable (30-day trend)
Autonomic Dysfunction Severity Index. Higher = more dysfunction.
GVHD Score
29.9/100
Wearable Activity | stable (30-day trend)
Composite from HRV, HR, sleep fragmentation, temperature. Ring-derived, not clinical diagnosis.
Recovery
93.8/100
Trajectory Index | stable (30-day trend)
Overall recovery trajectory. Higher = better.
Pharma
3.9Z
Ruxolitinib Response | worsening (30-day trend)
Pharmacodynamic response to ruxolitinib. Z-score relative to pre-treatment baseline.
CV Risk
Elevated45.8/100
Cardiovascular Composite | stable (30-day trend)
Cardiovascular risk proxy from resting HR, HRV, SpO2. Not equivalent to Framingham or SCORE2.
Allostatic
1.3/7
Load Score | stable (30-day trend)
Cumulative physiological stress burden. Scale 0-7.
REPORT SECTION
Summary
Post-HSCT Patient | 33.1 months post-HSCT | Ruxolitinib from 2026-03-16
| Biomarker | Value | Trend |
|---|---|---|
| ADSI | 59.0/100 | stable (30-day trend) |
| GVHD_SCORE | 29.9/100 | stable (30-day trend) |
| RECOVERY_INDEX | 93.8/100 | stable (30-day trend) |
| CV_RISK | 45.8/100 | stable (30-day trend) |
| ALLOSTATIC_LOAD | 1.3/7 | stable (30-day trend) |
HRV (RMSSD)
Significant163.8% change
p=0.0000, d=1.85 (large)
Lowest HR
Significant-19.7% change
p=0.0000, d=1.99 (large)
Average HR
Significant-17.2% change
p=0.0000, d=1.88 (large)
Sleep Efficiency
Significant5.1% change
p=0.0000, d=0.76 (medium)
| Metric | Pre-Rux (mean±SD) | Post-Rux (mean±SD) | Change | p-value | Cohen's d | Effect |
|---|---|---|---|---|---|---|
| HRV (RMSSD) | 10.0 ± 2.5 ms | 26.3 ± 10.3 ms | +163.8% | 0.0000 | 1.85 | large |
| Lowest HR | 76.7 ± 5.7 bpm | 61.6 ± 8.2 bpm | -19.7% | 0.0000 | 1.99 | large |
| Average HR | 85.2 ± 6.8 bpm | 70.6 ± 8.1 bpm | -17.2% | 0.0000 | 1.88 | large |
| Sleep Efficiency | 78.6 ± 3.4 % | 82.7 ± 5.9 % | +5.1% | 0.0000 | 0.76 | medium |
Three-Period Trajectory
Pre-acute (2026-02-09) → Post-acute/Pre-Rux → Post-Rux (2026-03-16)
HRV (RMSSD): 8.6 ms → 11.2 ms → 26.3 ms (acute event = inflection, Rux stabilized)
Lowest HR: 79.6 bpm → 74.1 bpm → 61.6 bpm (steady improvement)
Average HR: 88.7 bpm → 82.0 bpm → 70.6 bpm (steady improvement)
Sleep Efficiency: 78.1 % → 79.1 % → 82.7 %
Clinical note: The composite ADSI score dilutes these individual metric signals. While ADSI aggregates multiple domains into a single index, individual metrics like HRV and heart rate show statistically significant pre/post differences that the composite score may obscure through averaging.
REPORT SECTION